Updated 10/24/2025
GLP-1 medications, such as Semaglutide and Tirzepatide, are tools for weight loss and blood sugar management. However, they are not suitable for everyone. Certain individuals should avoid using these medications due to specific health conditions or risk factors. Here’s a comprehensive guide on who should avoid GLP-1 medications and why.
Who Should Avoid GLP-1 Medications?
Individuals with a History of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2):
Why: GLP-1 medications have been associated with an increased risk of thyroid tumors in animal studies. Although this risk has not been conclusively proven in humans, it is recommended to avoid these medications if you have a personal or family history of MTC or MEN 2.
Patients with a History of Pancreatitis:
Why: There is a potential risk of developing pancreatitis with GLP-1 medications. If you have a history of pancreatitis, you should avoid these medications to prevent recurrence or exacerbation of the condition.
Severe Gastrointestinal Disease:
Why: GLP-1 medications slow gastric emptying, which can exacerbate conditions like gastroparesis or severe gastrointestinal disease. Patients with these conditions should avoid GLP-1 medications to prevent worsening of symptoms.
Type 1 Diabetes:
Why: GLP-1 medications are not suitable for the treatment of Type 1 diabetes. These medications are designed to help with insulin resistance and weight loss, which are not typically the primary concerns in Type 1 diabetes management.
Severe Renal Impairment:
Why: GLP-1 medications are excreted through the kidneys. Patients with severe renal impairment may experience increased side effects and complications, making these medications unsuitable.
Allergic Reactions to GLP-1 Medications:
Why: If you have had an allergic reaction to any GLP-1 medication or its components, you should avoid using these medications to prevent severe allergic reactions.
Special Considerations
Pregnancy and Breastfeeding:
Why: There is limited data on the safety of GLP-1 medications during pregnancy and breastfeeding. It is recommended to avoid these medications if you are pregnant, planning to become pregnant, or breastfeeding.
Liver Disease:
Why: Patients with significant liver disease should use GLP-1 medications with caution. Your healthcare provider will assess the risks and benefits before prescribing these medications.
Use with Other Medications:
Why: Some medications may interact with GLP-1 medications, potentially leading to adverse effects. Always inform your healthcare provider of all medications you are taking to ensure there are no harmful interactions.
Consulting Your Healthcare Provider
Before starting GLP-1 medications, it is crucial to discuss your full medical history with your healthcare provider. This discussion should include any current health conditions, past medical history, and all medications and supplements you are taking. Your healthcare provider will help determine if GLP-1 medications are a suitable option for you.
Monitoring and Follow-Up
If you are prescribed GLP-1 medications, regular monitoring and follow-up appointments are essential. These check-ins help ensure the medication is working as well as possible, and allow your provider to make any necessary adjustments to your treatment plan.
Conclusion
While GLP-1 medications offer significant benefits for weight loss and blood sugar management, they are not appropriate for everyone.
If you have any questions or need further information, please reach out to our support team. Thank you for choosing GobyMeds. We are dedicated to supporting you on your journey to better health.
⚠️ Important Disclaimer About Compounded Medications
Compounded medications are custom-prepared by licensed compounding pharmacies based on an individual prescription from your healthcare provider. These formulations are designed to meet the specific needs of patients when an FDA-approved medication may not be available or suitable.
While compounded medications are made using active pharmaceutical ingredients sourced from FDA-registered suppliers, the final compounded product has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality.
GobyMeds works only with licensed 503A and 503B compounding pharmacies that adhere to strict federal and state quality standards for purity, potency, and sterile production.
Patients should always consult with their licensed healthcare provider before starting any compounded medication and report any unexpected side effects or concerns immediately.