Updated 10/24/2025

Sermorelin is a growth hormone–releasing hormone (GHRH) analog that helps stimulate your body’s natural production of growth hormone. It’s commonly used to support metabolism, recovery, sleep, and overall vitality.

While Sermorelin therapy is safe and well-tolerated for most people, it is not suitable for everyone.

Here’s a comprehensive guide to who should avoid Sermorelin and why.

Why: If you have ever experienced an allergic reaction (rash, swelling, difficulty breathing, or dizziness) to Sermorelin or any of its components, you should not use this medication.

Why: Sermorelin stimulates the release of growth hormone, which can promote cellular growth. This may worsen or accelerate the growth of existing tumors or cancers. Individuals with active malignancies or a history of pituitary, breast, or prostate cancer should avoid Sermorelin unless cleared by their oncologist.

Why: Because Sermorelin acts directly on the pituitary gland, those with pituitary tumors or structural abnormalities may experience unpredictable or harmful effects.

Why: There is insufficient data on the safety of Sermorelin during pregnancy and breastfeeding. It should be avoidedduring these times unless your provider determines the potential benefit outweighs the risk.

Why: Sermorelin affects hormone production and should be used cautiously in patients with uncontrolled thyroid disease, adrenal disorders, or diabetes. These conditions can interfere with how Sermorelin works and lead to unpredictable results.

Why: Sermorelin may increase growth hormone and IGF-1 levels, which can cause mild fluid retention. For individuals with heart failure, uncontrolled hypertension, or severe sleep apnea, this can worsen symptoms.

Why: Sermorelin is not intended for performance enhancement or non-medical use. It should only be prescribed to individuals who have been properly evaluated for hormone deficiency.

Why: Combining Sermorelin with other hormone therapies—such as testosterone, growth hormone, or thyroid medication—can alter hormonal balance.
​Management Tips: Always tell your provider about any hormone or supplement regimen you are using so your plan can be adjusted safely.

Why: Steroid medications can inhibit Sermorelin’s ability to stimulate growth hormone release.
​Examples: Prednisone, dexamethasone, hydrocortisone.
​Management Tips: Your provider may adjust your dosing schedule or recommend spacing medications apart to reduce interference.

Before starting Sermorelin therapy, it’s important to discuss your complete medical history with your provider. This includes:

Your provider will evaluate whether Sermorelin is appropriate for you and determine the safest dosage and frequency.

If you begin Sermorelin therapy, regular check-ins are essential to ensure treatment safety and effectiveness.
Your provider may:

Contact your provider immediately if you experience unusual swelling, headaches, vision changes, or any signs of an allergic reaction.

While Sermorelin therapy can provide significant benefits for sleep, metabolism, and vitality, it isn’t suitable for everyone. Understanding the contraindications and maintaining open communication with your provider will help ensure the best possible treatment plan.
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At GobyMeds, your health and safety are our priority. If you have any questions about Sermorelin therapy or whether it’s right for you, please contact our support team or reach out to your provider through your Patient Portal.
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Thank you for choosing GobyMeds. We’re honored to support your journey toward better energy, balance, and overall well-being.