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Understanding how your compounded NAD+ therapy may interact with other medications or supplements is important for ensuring both safety and effectiveness. NAD+ (nicotinamide adenine dinucleotide) plays a vital role in cellular energy production, metabolism, and DNA repair, and certain substances can influence its absorption, metabolism, or therapeutic benefits.

Here’s what you should know about potential interactions and how to manage them safely.

Interaction: NAD+ is derived from niacin (vitamin B3). Taking large doses of additional niacin or niacinamide supplements while using NAD+ may cause overlapping effects, flushing, or nausea.
​Management Tips: Avoid high-dose vitamin B3 supplements unless directed by your provider. Typical multivitamin levels are safe.

Interaction: NAD+ can promote vasodilation (widening of blood vessels), which may slightly lower blood pressure. When combined with antihypertensive drugs, it could enhance this effect.
​Examples: Lisinopril, amlodipine, losartan, or hydrochlorothiazide.
​Management Tips: Monitor your blood pressure regularly and report any dizziness or lightheadedness to your provider. Dosage adjustments may be needed.

Interaction: NAD+ may improve insulin sensitivity and glucose metabolism. When combined with diabetes medications, this could increase the risk of low blood sugar (hypoglycemia).
​Examples: Metformin, insulin, glipizide.
​Management Tips: Monitor blood sugar closely, especially when starting therapy. Notify your provider if you experience shakiness, sweating, or fatigue.

Interaction: NAD+ supports cellular repair and regeneration, which may theoretically influence how certain chemotherapy agents work.
​Management Tips: Always discuss NAD+ use with your oncologist or provider before or during cancer treatment.

Interaction: Some antibiotics—particularly fluoroquinolones—can affect mitochondrial function, which overlaps with NAD+’s mechanism of action.
​Examples: Ciprofloxacin, levofloxacin.
​Management Tips: Inform your provider if you are prescribed these antibiotics. In most cases, short-term antibiotic use is safe but should be monitored.

Interaction: Chronic alcohol use depletes NAD+ levels in the body and may reduce the benefits of supplementation.
​Management Tips: Limit or avoid alcohol while using NAD+ therapy for best results.

Interaction: NAD+ may amplify the effects of other metabolic or energy-support supplements.
​Examples: CoQ10, resveratrol, caffeine-based products.
​Management Tips: Avoid taking multiple energy-enhancing supplements without consulting your provider to prevent overstimulation, headaches, or jitteriness.

Always give your provider a full list of everything you’re taking, including:

Report any unusual side effects such as dizziness, flushing, low blood pressure, or fatigue to your provider right away.

Follow up with your provider periodically to review your treatment progress and discuss any new medications you’ve started.

Do not start, stop, or change the dosage of NAD+ or any other medication without first consulting your healthcare provider.

Make sure to disclose all current medications you are taking when completing your intake form at GobyMeds. Most people tolerate NAD+ well when it’s used as prescribed and monitored by a qualified provider.

At GobyMeds, your safety and success come first. If you have questions about NAD+ or how it may interact with other medications or supplements, please reach out to your provider through your Patient Portal or contact the GobyMeds support team for guidance.
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Thank you for choosing GobyMeds. We’re here to help you feel more energized, focused, and healthy.