NAD+ Medication Guide

NAD⁺ stands for Nicotinamide Adenine Dinucleotide—a coenzyme present in every living cell. It’s derived from niacin (vitamin B3) and is essential for cellular energy production. In the body, NAD⁺ alternates between two forms: NAD⁺ (oxidized) and NADH (reduced), helping shuttle electrons during metabolic processes that produce ATP, the body’s primary energy source.

Why is NAD⁺ Important?
NAD⁺ supports a wide range of critical functions:

How NAD⁺ Affects Aging
NAD⁺ levels peak when we’re young and healthy but decline significantly with age, stress, poor diet, and environmental toxins. This decline contributes to reduced energy, slower metabolism, cognitive decline, and an increased risk of age-related diseases. NAD⁺ therapy aims to restore these levels, promoting better cellular function and a healthier aging process.

It stands for Nicotinamide Adenine Dinucleotide—a coenzyme found in all living cells that helps with energy production and cell repair.

Natural aging, stress, inflammation, and environmental damage all contribute to lower NAD⁺ levels, which in turn impact our cells’ ability to function optimally.
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Low NAD⁺ can lead to fatigue, cognitive issues, poor metabolism, and more visible signs of aging. In extreme deficiency (such as from niacin deficiency), it can result in a serious condition called pellagra.
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Yes, NAD⁺ is a molecule your body naturally produces. Supplementing or restoring it simply brings levels back to a more youthful, optimal state.

NAD⁺ is often called a “helper molecule” because it binds to and activates other enzymes, enabling essential functions throughout the body. Its most fundamental role is in cellular energy production. In processes like glycolysis and the citric acid cycle, NAD⁺ accepts electrons and becomes NADH. This transfer helps drive ATP production — the energy currency of every cell. Without enough NAD⁺, cells struggle to produce energy, leading to fatigue and cellular dysfunction.

NAD⁺ and DNA Repair
NAD⁺ is also crucial for maintaining cellular integrity. It fuels enzymes like:

Both types of enzymes consume NAD⁺ while doing their job. That means NAD⁺ isn’t just used — it’s burned up during critical cellular repairs and stress responses. This makes replenishment key for staying healthy and resilient over time.

How NAD⁺ Levels Decline
Aging, poor sleep, chronic stress, alcohol, and bad diet can all lower NAD⁺ levels or increase how quickly it’s used up. As NAD⁺ drops, our body’s ability to generate energy and fix DNA declines — contributing to fatigue, cognitive decline, and other age-related issues.

Why NAD⁺ Therapy Helps
Supplementing NAD⁺ directly (or with its precursors) can restore cellular function, improve energy, and reactivate those important repair and longevity pathways. Essentially, NAD⁺ therapy tops off the body’s reserves so your cells can keep working at full power.

NAD⁺ is required to convert food into cellular energy (ATP). Without it, cells can’t power vital functions.

It fuels enzymes like PARPs and sirtuins, which detect and repair DNA damage, reduce inflammation, and regulate how genes behave under stress.

Aging, stress, poor sleep, alcohol, and a poor diet all deplete NAD⁺ levels or increase how fast it's used up.

Yes — through diet, exercise, sleep, and supplements. However, NAD⁺ therapy offers a faster and more targeted way to restore optimal levels and support long-term cellular health.

What is NAD⁺ Therapy?
NAD⁺ therapy is the process of supplementing or restoring NAD⁺ levels in the body to help your cells function at their best. As we age or face stress, NAD⁺ levels naturally drop—leading to fatigue, mental fog, poor metabolism, and faster cellular aging. Restoring NAD⁺ levels helps reverse some of these effects by powering up energy production, DNA repair, and inflammation control.

Top Benefits of NAD⁺ Therapy

✔️ Supports Healthy Aging
NAD⁺ activates sirtuins (aka “longevity genes”) and fuels DNA repair. Higher NAD⁺ levels are linked to better resilience against aging, improved organ function, and protection from age-related decline. Some research even suggests it may slow down biological aging and extend healthspan.

✔️ Increases Energy & Metabolism
NAD⁺ is essential for turning food into energy. By restoring NAD⁺, the body becomes more efficient at producing ATP, which boosts energy and endurance. It can also support fat metabolism, improve insulin sensitivity, and help with weight management—especially in those who are overweight or metabolically sluggish.

✔️ Enhances Brain Function
The brain uses a lot of energy and needs NAD⁺ to stay sharp. Many patients report better focus, memory, and mood after starting NAD⁺ therapy. NAD⁺ may even protect against neurodegeneration and age-related cognitive decline by improving nerve cell repair and reducing inflammation in the brain.

✔️ Speeds Up Recovery & Cellular Repair
Whether you're bouncing back from a workout, surgery, or stress, NAD⁺ supports faster recovery by fueling repair enzymes in your body. It also enhances immune function and reduces inflammation—making your cells more resilient. Some clinics even use high-dose NAD⁺ for addiction recovery and brain restoration.

✔️ Improves Heart & Metabolic Health
NAD⁺ helps maintain healthy blood vessels, lowers oxidative stress, and supports liver function. Studies show it may reduce blood pressure, cholesterol, and inflammation—key factors in heart disease, diabetes, and metabolic syndrome.

✔️ Promotes Youthful Skin
NAD⁺ helps skin cells repair UV and environmental damage. Users often report improved skin texture, hydration, firmness, and glow. Some research even shows NAD⁺ may reduce the risk of certain skin cancers by improving cellular DNA repair capacity.

Why It Matters
NAD⁺ therapy doesn’t act like a stimulant—it works at the foundational level to restore how your cells perform. Think of it as “recharging your internal batteries” and giving your body what it needs to function optimally, not just temporarily feel better. With consistency, the effects compound and can transform how you age and feel.

Increased energy, better focus, enhanced metabolism, improved recovery, healthier skin, and slowed aging.

Some people feel more energy or mental clarity within a week, but most see noticeable changes after 4–8 weeks of consistent use.

Yes, it uses a molecule naturally found in the body. It’s generally well-tolerated and safe when used under medical supervision.

Anyone experiencing fatigue, brain fog, poor metabolism, or looking for anti-aging support. It's especially useful for people 30+ who want to maintain vitality and long-term health.

How It Works
NAD⁺ injections deliver a precise dose of NAD⁺ into subcutaneous tissue (belly, thigh, or back of the arm). From there, NAD⁺ slowly enters the bloodstream and supports energy production, DNA repair, and cell function. This method avoids the digestive system, ensuring maximum absorption.
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Dosing Guidelines
Most patients start at 20–50 mg per injection, typically once or twice weekly. Over time, this may increase up to 100 mg based on tolerance and goals. A common reference: 0.5 mL = ~100 mg NAD⁺.
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What Patients Feel
Effects are subtle but build over time. Some patients notice a mild boost in energy or clarity within a few hours. With consistent use, they may report better recovery, less fatigue, and more stable energy throughout the week.
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Advantages

Considerations

How It Works
The spray is absorbed through the nasal mucosa, bypassing digestion and entering the bloodstream and potentially even the brain quickly. This makes it excellent for cognitive and mood support.

Dosing Guidelines
Each spray delivers a small dose (around 5 mg). Patients typically use 1–2 sprays per nostril daily, based on their prescription. Most use it in the morning or early afternoon to avoid interference with sleep.

What Patients Feel
Mental sharpness, clearer thinking, reduced brain fog,sometimes within minutes. While the energy effects are more subtle than injections, the nootropic effects are often more immediate.

Advantages

Considerations

Injection is ideal for:

Nasal Spray is ideal for:

Some patients use both: a weekly injection to build and maintain NAD⁺ levels, plus nasal spray for cognitive support during busy days.

Injections deliver higher NAD⁺ doses systemically, great for energy and recovery. Nasal spray delivers lower doses but may work faster for mental clarity.

Most patients find them easy and minimally uncomfortable. GobyMeds provides everything needed for safe at-home use.

Injections have longer-lasting, systemic effects. Nasal spray tends to work quicker but requires daily use for full benefit.

Short answer is yes. Many patients use injections for baseline NAD⁺ support and nasal spray for added brain boosts during the week. However, we will only be prescribing one type or the other to our patients. Beluga isn't setup currently to prescribe both at one time. This may change in the future though.

Within the First Week
Most patients don’t feel a huge shift in the first few days, but subtle benefits can begin. Common early effects include:

Not everyone feels these effects right away, and that’s normal. Early on, NAD⁺ may be quietly repairing cellular damage or restoring internal balance before big changes are noticeable. This is a building phase — stay consistent.

By 1 Month (4 Weeks)
This is when most patients start noticing real changes:

Patients often say they feel “more like themselves” or like they’re operating at a higher gear during this phase.

2–3 Months
Now the NAD⁺ is deeply integrated into cellular function, and results are more pronounced:

This is a key checkpoint — many patients feel truly transformed at this stage and may choose to maintain or slightly reduce their dosing going forward.

6 Months and Beyond
NAD⁺ therapy now becomes a part of your wellness routine, and the long-term benefits are deeply set:

Most patients at this stage choose to continue NAD⁺ therapy with a maintenance dose, appreciating both how they feel and the cellular defense NAD⁺ provides.

Some people feel subtle energy or mental clarity within a few days. Most start seeing consistent, noticeable changes between weeks 2–4.

Week 1 - subtle changes.
Week 4 - clearer energy, sharper mind.
Month 2–3 - big transformation in vitality, mood, recovery, and skin.
Month 6+ - lasting improvements in health and appearance in mental clarity and skin.

That’s totally normal. NAD⁺ often works silently behind the scenes to repair cells. Stay consistent — many effects take time and build over weeks.

Some benefits may gradually taper off, but most patients retain improvements for a while. To maintain peak performance and anti-aging protection, we recommend sticking with a maintenance dose.

1. Energy Production and Fatigue Relief
NAD⁺ powers your mitochondria — the engines of your cells. It helps turn nutrients into ATP, the body’s usable energy. Low NAD⁺ means inefficient energy production, leading to tiredness and brain fog. Raising NAD⁺ levels can dramatically improve endurance and energy by helping your cells “breathe” and burn fuel better.

2. Blood Sugar and Insulin Sensitivity
NAD⁺ helps regulate how your cells respond to insulin and process glucose. Research shows NAD⁺ boosters improve insulin sensitivity and may lower blood sugar. This supports better energy levels and reduces the risk of prediabetes or type 2 diabetes. Some users also experience fewer cravings due to more stable blood sugar.

3. Fat Metabolism and Weight Control
NAD⁺ is involved in breaking down fats for energy and activating AMPK — a cellular signal that tells your body to burn fat. Increasing NAD⁺ may help shift your body toward fat-burning mode and reduce stubborn weight (especially around the belly). Some patients also notice a slight appetite reduction or better satiety.

4. Cardiovascular and Cholesterol Support
NAD⁺ has been shown to lower LDL (bad) cholesterol and triglycerides in some studies. It may also improve blood vessel health and lower blood pressure. These effects make it a powerful tool for reducing the risk of metabolic syndrome and supporting heart health over time.

5. Muscle Metabolism and Fitness
Higher NAD⁺ levels support muscle energy and recovery. This can help with strength, endurance, and fat-burning capacity. NAD⁺ therapy may help patients exercise more effectively and recover faster, which fuels a positive cycle of movement and weight management.

6. Liver Health and Detox Efficiency
NAD⁺ is vital for liver function and detoxification. It supports antioxidant production (like glutathione) and enzymes that clear waste and toxins. A healthy liver helps regulate cholesterol, blood sugar, and fat storage, keeping your metabolic engine running clean.

It can indirectly. NAD⁺ supports healthy fat metabolism, insulin sensitivity, and energy use. These changes help with weight control, especially when combined with healthy habits.

No. NAD⁺ doesn’t spike energy like a stimulant. Instead, it restores natural energy production over time, giving you steady, clean energy without jitters or crashes.

Yes. Studies show improved insulin response and better blood sugar balance with NAD⁺ therapy, which can help reduce cravings and support appetite control.

NAD⁺ therapy may help lower LDL and triglycerides while improving blood vessel function — all key to preventing heart disease or metabolic syndrome.

1. DNA Repair and Protection from Sun Damage
Skin aging is largely driven by UV-induced DNA damage. Enzymes like PARPs and sirtuins repair this damage, but they require NAD⁺ to function. Without enough NAD⁺, repair slows and damage accumulates — leading to wrinkles, age spots, and increased cancer risk. NAD⁺ therapy boosts your skin’s ability to fix daily sun damage and maintain cellular health, essentially slowing down photoaging and keeping skin resilient.

2. Collagen Support and Elasticity
NAD⁺ supports fibroblasts — the cells responsible for producing collagen and elastin. With age, collagen levels naturally decline. Replenishing NAD⁺ helps maintain these structural proteins, keeping skin firmer, smoother, and more elastic. Some patients report visibly thicker or “bouncier” skin and softer fine lines after a few months of NAD⁺ therapy.

3. Improved Skin Barrier and Hydration
NAD⁺ helps generate ceramides — essential lipids that strengthen the skin barrier and lock in moisture. This improves skin hydration and helps prevent dryness or irritation. It may also support patients with eczema, rosacea, or other barrier-related conditions by making the skin more resilient and less reactive.

4. Skin Cancer Prevention
Clinical research shows that NAD⁺ precursors like nicotinamide reduce the risk of certain skin cancers by enhancing DNA repair. While not a replacement for sunscreen, NAD⁺ therapy adds internal protection against the UV-induced cell mutations that lead to squamous and basal cell carcinoma.

5. Radiance and Overall Appearance
With improved cellular turnover and reduced inflammation, patients often notice a clearer, more radiant complexion. NAD⁺ helps reduce redness, acne, and uneven tone. It also supports skin detox and renewal, contributing to a “glow from within” effect after consistent use.

Yes. NAD⁺ supports collagen and elastin production, helping reduce fine lines and improve skin firmness over time.

Yes. By supporting ceramide production and skin barrier function, NAD⁺ may improve hydration and skin resilience.

No. It complements topical skincare and sun protection by working from within to strengthen and protect skin cells.

Some users notice subtle changes within 4–6 weeks. More noticeable results (like improved tone or elasticity) typically appear by 2–3 months.

Yes. Oral B3 has limited absorption and side effects like flushing. NAD+ injections or sprays bypass digestion, offering more direct, efficient cellular support.

Very. Side effects are mild and rare – typically minor injection-site irritation or slight nasal dryness. We monitor your health throughout the process to ensure everything is going smoothly.

Minor issues like flushing, redness, mild nausea, or nasal irritation may occur. These are easily managed. We help adjust dosing if needed.

Not advised during pregnancy, breastfeeding, active cancer, or severe liver/kidney issues. We review your medical history to ensure it's right for you.

Injections are quick and virtually painless with a tiny needle. Nasal spray is as easy as using Flonase. We provide instructions and support.

Some feel energized or clear-headed in the first week. Most see noticeable benefits in 3–4 weeks, with stronger effects after 2–3 months.

Use it for 3 months minimum to feel full benefits. Some stop after achieving goals; others continue for ongoing anti-aging and wellness. It’s flexible and non-habit forming.

Yes – NAD+ improves metabolism, recovery, and energy, which can amplify your weight loss or fitness efforts. But it works best alongside diet and exercise.

Yes. NAD+ supports DNA repair, sirtuin activity, and healthy mitochondria – all linked to slower aging. Animal studies and human trials back this up.

No unless there's a preexisting health concern that you should discuss with your primary healthcare provider. Labs can be added if you like measuring progress outside of your GobyMeds treatment.

Not as a branded drug, but it’s legal and ethical through compounding pharmacies with a prescription. It’s widely used in wellness and anti-aging care.

We combine medical expertise, personalized care, home delivery, and educational support. We want to see you at your best and are always here to help!